There are no official guidelines yet on the use of disease-modifying oral treatments due to their recent development.  While some believe that they will probably reduce the usage of first-line treatments the long-term safety of interferons and glatiramer acetate will probably slow this trend.  It has been recommended that at the moment oral treatments should be mainly offered in those cases where patients do not use existing treatments due to needle phobia or other reasons such as perceived inefficacy of interferons and glatiramer acetate.  They could also be used in patients taking natalizumab who have developed JC virus antibodies and are therefore at an increased risk of PML.  Dimethyl fumarate is potentially one of the most interesting oral drugs due to the long term data from use in psoriasis which points towards a very good safety profile. 
Q. What is MS? I am 14 years old and my best friend has been diagnosed with MS. What is it? What causes it? Can I catch it? A. Multiple sclerosis (MS) is an autoimmune disease in which the body's immune system attacks the central nervous system (CNS), causing demyelination (loss of myelin). The myelin sheath helps the neurons (nerves) carry electrical signals. When having MS there is a thinning or complete loss of myelin and, sometimes, the cutting of the neuron's extensions or axons. When the myelin is lost, the neurons can no longer effectively conduct their electrical signals. It may cause numerous physical and mental symptoms. MS is not contagious and does not shorten the life expectancy of those who are diagnosed with the disease. Although the disease may not be cured or prevented at this time, treatments are available to reduce severity and delay progression.